Cabergoline is a synthetic ergot derivative, which is a potent dopamine receptor agonist on D2 receptors. It acts on dopamine receptors of prolactin producing cells in the pituitary gland suppressing the prolactin production and leading to the inhibition of prolactin secretion dependent process. Consequently, cabergoline administration induces a reduction of milk production leading to a reduction in udder engorgement and intramammary pressure. Subsequently udder pain and discomfort are reduced at one and two days after drying off, respectively.

After intramuscular administration in cattle, the systemic absorption of cabergoline is rapid and important (bioavailability over 90%), with a peak concentration observed around 3 h after administration and followed by a high tissue distribution. More than 74% of cabergoline is bound to plasma protein. Cabergoline is rapidly metabolized principally by liver and is eliminated with a mean half-life of about 20 hour. Approximately 66% of the administered dose is eliminated by faeces. Urine is the second pathway of elimination.

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VELACTIS^® is indicated for cattle.

It facilitates the abrupt drying-off by reducing milk production to:

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• reduce milk leakage at drying off,
• prevent new intramammary infections during the dry period,
• reduce pain and discomfort.

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