Toltrazuril is a triazinon derivative and an antiprotozoal agent. It has coccidiocidal activity against all intracellular development stages of the genera Cystoisospora, that is, merogony (asexual multiplication) and gamogony (sexual phase).
Iron is an essential micronutrient. It plays a major role in the transport of oxygen via haemoglobin and myoglobin, as well as having a key role in enzymes, such as cytochromes, catalases, and peroxidases. Injectable iron-carbohydrate complexes, such as gleptoferron, are established haematinic agents in veterinary medicine and are effective in significantly increasing the haemoglobin levels in piglets raised under intensive farming conditions in which an all milk diet for several weeks does not provide an adequate source of iron. Following intramuscular injection, gleptoferron is absorbed and metabolised to release the iron for use and/or storage in accordance with the nutritional status of the animal. Excess iron is stored principally in the liver.
FORCERIS®is indicated for Pigs (piglets 1-3 days old) for the concomitant prevention of iron deficiency anaemia and prevention of clinical signs of coccidiosis (diarrhoea) as well as reduction in oocyst excretion, in farms with a confirmed history of coccidiosis caused by Cystoisospora suis.
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COMPOSITION
Each 1 ml:
Toltrazuril ……………………………………..…….. 30 mg
Iron (III) ……………………………………..……..133.4 mg
(as Gleptoferron) ……………………………….....355.2 mg
Excipient…………….qs…….………………………. 1 ml.
DOSAGE AND ADMINISTRATION
Piglets: Intramuscular use.
Shake well (for 20 seconds) before use.
The recommended dose is 45 mg of toltrazuril and 200 mg of iron per piglet, that is, 1.5 mL of FORCERIS®suspension per piglet, to be administered once, in a single intramuscular injection behind the ear, between 1 and 3 days of age (i.e. 24 to 96 hours after birth).
CONTRAINDICATION
Do not use in piglets suspected to be suffering from a deficiency of vitamin E and/or selenium.
OVERDOSE
In safety study, after any overdosage, an increased susceptibility for (systemic) bacterial disease, arthritis, and abscess formation was observed and a dose-dependant increase in mortality could not be excluded.
During overdosage study, a slight transient reduced erythrocyte count without clinical signs was observed after day 21 following single administration at three times the recommended dose (135 mg/piglet toltrazuril and 600 mg/piglet iron).
Doses higher than 135 mg/piglet and 600 mg/piglet for toltrazuril and iron respectively, i.e. 3 times the recommended dose, have not been evaluated in the target animal safety study. The tolerance of the product after repeated administrations has not been assessed.
WITHDRAWAL PERIOD
Meat and offal:
– Pigs: 70 days
PRESENTATION
Bottle (100; 250 ml).
STORAGE
Store at temperature below 30°C.
Once broached, it can be used within 28 days, if kept at temperature below 30°C.
Keep out of reach of children.
FOR ANIMAL TREATMENT ONLY
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