Ceftiofur is a third generation of Cephalosporin, which is active against many Gram-positive and Gram-negative bacteria, including ß –lactamase producing strains. Ceftiofur inhibits the bacterial cell wall synthesis, thereby exerting its bactericidal properties. Beta-lactams act by interfering with synthesis of the bacterial cell wall.
After administration, Ceftiofur is quickly metabolised to desfuroylceftiofur, the principal active metabolite. Desfuroylceftiofur has an equivalent anti-microbial activity to Ceftiofur against the bacteria involved in respiratory disease in animals. The active metabolite is reversibly bound to plasma proteins. Due to transportation with these proteins, the metabolite concentrates at a site of infection, is active and remains active in the presence of necrotic tissue and debris.
If you have any questions, please do not hesitate to contact us or send us an e-mail to contact.vn@ceva.com!
COMPOSITION
Ceftiofur (as hydrochloride)............................................................ 50 mg
Excipients q.s..................................................................................... 1.0 ml
DOSAGE
Cattle:
Subcutaneous use.
- Respiratory disease: 1 mg Ceftiofur (as hydrochloride)/kg/day for 3 to 5 days, i.e. 1 ml/50 kg at each injection.
- Acute interdigital necrobacillosis: 1 mg Ceftiofur (as hydrochloride)/kg/day for 3 days, i.e. 1 ml/50 kg at each injection.
- Acute post-partum metritis within 10 days after calving: 1 mg Ceftiofur (as hydrochloride)/kg/day for 5 consecutive days, i.e. 1 ml/50 kg at each injection.
Pigs:
Intramuscular use.
3 mg Ceftiofur (as hydrochloride)/kg/day for 3 days i.e. 1 ml/16 kg at each injection.
Shake the bottle well before use to bring the product back into suspension.
To ensure a correct dosage, body weight should be determined as accurately as possible in order to avoid underdosing.
Subsequent injections must be given at different sites.
As the vial cannot be broached more than 50 times, the user should choose the more appropriate vial size.
CONTRAINDICATION
The bactericidal properties of Cephalosporins are antagonized by simultaneous use of bacteriostatic antibiotics (Macrolides, Sulfonamides and Tetracyclines).
WITHDRAWAL PERIOD
Cattle:
- Meat and offal: 2 days.
- Milk: 0 hours.
Sows:
- Meat and offal: 3 days.
PRESENTATION
Bottle (50; 100; 250; 500 ml).
STORAGE
Store at room temperature, protected from light.
Once broached, it can be used within 28 days if keep in refrigerator.
Keep out of reach of children.
FOR ANIMAL TREATMENT ONLY